Synthesis, Characterization And Antibacterial Properties Of Nickel (Ii) Amine Malonate And Nickel (Ii) Amine Tartarate

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ABSTRACT

Nickel amine carboxylate complexes were synthesized by reacting Ni(ii)chloride with ammonia, malonic and tartaric acid, which formed Nickel amine malonate and Nickel amine tartarate of blue and green crystal and the percentage yield are of both complexes are 62.65% and 62.83% respectively. The decomposition temperatures were 218o C and 203oC with percentage moisture content of 8.0% and 21.50%. The carboxylic acids and the synthesized complexes were tested for antibacterial activity on Escherichia coli at concentrations of 5mg, 10mg, and 15mg.The zone of inhibition given by the complexes were 35mm,40mm,48mm for the malonate complex and 31mm, 37mm and 42mm for the tartarate complex. In the infrared spectra the presence of M-N, M-O and C-H bonding revealed the bonding of the metal ion to the ligands to form complexes.

Table of Content

CHAPTER ONE

1.0 Introduction 1

1.1 Transition elements 1

1.2 Complex compound 2

1.3 Ligand 5

1.4 Antibacterial property 6

1.5 Statement of problem¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬ 8

1.6 Justification 8

1.7 Aim and objectives 9

1.8 Scope 9

CHAPTER TWO

2.0 Literature review 10

2.1 Nickel complexes 11

2.2 Nickel amine complexes 13

2.3 Amine carboxylate complexes 17

2.4 Antibacterial application 20

CHAPTER THREE

3.0 Methodology 24

3.1 Materials 24

3.2 Synthesis of nickel amine carboxylate complexes 24

3.2.1 Synthesis of nickel amine malonate 24

3.2.2 Synthesis of nickel amine tartarate 25

3.3 Characterization of nickel amine carboxylate complexes 25

3.3.1 Physical properties 25

3.3.2 Solubility test 25

3.3.3 Melting point 26

3.3.4 Determination of moisture content 26

3.3.5 Infrared spectroscopy analysis 26

3.4. Antibacterial activity 26

CHAPTER FOUR

4.0 Results 28

CHAPTER FIVE

5.0 Discussion 32

5.1 Conclusion 33

5.2 Recommendations 33

Reference 34

Appendix IA 36

Appendix IB 38

Appendix II 40

LIST OF TABLES

Table 4.1 Percentage Yield of the complexes 28

Table 4.2 Physical properties of the complexes 28

Table 4.3 Solubility test 29

Table 4.4 Antibacterial Activity of the compounds 30

Table 4.5 Infrared spectral data of the complexes 31

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Synthesis, Characterization And Antibacterial Properties Of Nickel (Ii) Amine Malonate And Nickel (Ii) Amine Tartarate

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